Journal
JOURNAL OF CELL SCIENCE
Volume 123, Issue 3, Pages 309-320Publisher
COMPANY BIOLOGISTS LTD
DOI: 10.1242/jcs.061739
Keywords
Live-cell imaging; Macromolecular assemblies; Signal transduction
Categories
Funding
- MRC [G0700771] Funding Source: UKRI
- Medical Research Council [G0700771] Funding Source: researchfish
- Biotechnology and Biological Sciences Research Council Funding Source: Medline
- Medical Research Council [G0700771] Funding Source: Medline
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Signalling molecules integrate, codify and transport information in cells. Organisation of these molecules in complexes and clusters improves the efficiency, fidelity and robustness of cellular signalling. Here, we summarise current views on how signalling molecules assemble into macromolecular complexes and clusters and how they use their physical properties to transduce environmental information into a variety of cellular processes. In addition, we discuss recent innovations in live-cell imaging at the sub-micrometer scale and the challenges of object (particle) tracking, both of which help us to observe signalling complexes and clusters and to examine their dynamic character.
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