Journal
JOURNAL OF CELL SCIENCE
Volume 122, Issue 4, Pages 453-459Publisher
COMPANY BIOLOGISTS LTD
DOI: 10.1242/jcs.037200
Keywords
CD36; Macrophage fusion; IL-4; Multinucleated giant cell; Mouse
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Funding
- German Research Foundation (DFG)
- Medical Research Council (MRC)
- German Academic Exchange Service (DAAD)
- Medical Research Council [G0600727] Funding Source: researchfish
- MRC [G0600727] Funding Source: UKRI
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Multinucleated giant cells, characteristic of granulomatous infections, originate from the fusion of macrophages. Using an antibody screening strategy we found that the scavenger receptor CD36 participates in macrophage fusion induced by the cytokines IL-4 and GM-CSF. Our results demonstrate that exposure of phosphatidylserine on the cell surface and lipid recognition by CD36 are required for cytokine-induced fusion of macrophages. We also show that CD36 acts in a heterotypic manner during giant-cell formation and that the formation of osteoclasts is independent of CD36. The discovery of molecules involved in the formation of multinucleated giant cells will enable us to determine their functional significance. Furthermore, our results suggest that lipid capture by cell surface receptors may be a general feature of cell fusion.
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