Journal
JOURNAL OF CELL SCIENCE
Volume 122, Issue 12, Pages 1947-1953Publisher
COMPANY BIOLOGISTS LTD
DOI: 10.1242/jcs.038125
Keywords
Ena/VASP; VASP; Mena; Actin; Capping; Filopodia; Lamellipodia
Categories
Funding
- NIH [GM 083035, GM 58801]
Ask authors/readers for more resources
Ena/VASP proteins are conserved regulators of actin dynamics that have important roles in several physiological processes such as morphogenesis, axon guidance, endothelial barrier function, and cancer cell invasion and metastasis. Although considerable evidence points towards an anti-capping mechanism for Ena/VASP function, some controversy remains. Here, we evaluate the evidence for and against the anti-capping hypothesis, including results from some recent structural and biochemical studies that shed new light on this issue. In addition, we describe several alternate mechanisms that Ena/VASP proteins may utilize to regulate actin dynamics in vivo, including inhibition of branching, bundling and profilin-actin recruitment.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available