Journal
JOURNAL OF CELL SCIENCE
Volume 122, Issue 21, Pages 3837-3850Publisher
COMPANY BIOLOGISTS LTD
DOI: 10.1242/jcs.056127
Keywords
PIP5K1; PIP5K; PtdIns(4,5)P-2; Phosphatidylinositol; Phosphatidylinositol (4,5)-bisphosphate; Phosphatidylinositol 4-phosphate 5-kinase
Categories
Ask authors/readers for more resources
It has long been known that phosphoinositides are present in cellular membranes, but only in the past four decades has our understanding of their importance for proper cell function advanced significantly. Key to determining the biological roles of phosphoinositides is understanding the enzymes involved in their metabolism. Although many such enzymes have now been identified, there is still much to learn about their cellular functions. Phosphatidylinositol 4-phosphate5-kinases (PIP5Ks) are a group of kinases that catalyse the production of phosphatidylinositol (4,5)-bisphosphate [PtdIns(4,5)P-2]. As well as being a substrate for the enzymes phospholipase C (PLC) and phosphatidylinositol 3-kinase (PI3K), PtdIns(4,5)P-2 acts as a second messenger in its own right, influencing a variety of cellular processes. In this Commentary, we review how PIP5Ks are modulated to achieve regulated PtdIns(4,5)P-2 production, and discuss the role of these proteins in different cellular processes.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available