Journal
JOURNAL OF CELL SCIENCE
Volume 122, Issue 20, Pages 3605-3612Publisher
COMPANY OF BIOLOGISTS LTD
DOI: 10.1242/jcs.041210
Keywords
Chaperone; Endoplasmic reticulum; Membrane integration; Post-translational
Categories
Funding
- BBSRC [BB/D007879/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/D007879/1] Funding Source: researchfish
- Biotechnology and Biological Sciences Research Council [BB/D007879/1] Funding Source: Medline
- Wellcome Trust [081671] Funding Source: Medline
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Tail-anchored proteins are a distinct class of integral membrane proteins located in several eukaryotic organelles, where they perform a diverse range of functions. These proteins have in common the C-terminal location of their transmembrane anchor and the resulting post-translational nature of their membrane insertion, which, unlike the co-translational membrane insertion of most other proteins, is not coupled to ongoing protein synthesis. The study of tail-anchored proteins has provided a paradigm for understanding the components and pathways that mediate post-translational biogenesis of membrane proteins at the endoplasmic reticulum. In this Commentary, we review recent studies that have converged at a consensus regarding the molecular mechanisms that underlie this process-namely, that multiple pathways underlie the biogenesis of tail-anchored proteins at the endoplasmic reticulum.
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