Journal
JOURNAL OF CELL SCIENCE
Volume 122, Issue 7, Pages 976-984Publisher
COMPANY BIOLOGISTS LTD
DOI: 10.1242/jcs.037291
Keywords
Checkpoint activation; Endoplasmic reticulum-associated degradation; Unfolded protein response
Categories
Funding
- National Institutes of Health [DK064232, GM47533, RR005351, DK075322]
- Alpha1-Foundation [R06-06]
Ask authors/readers for more resources
The secretory pathway provides a physical route through which only correctly folded gene products are delivered to the eukaryotic cell surface. The efficiency of endoplasmic reticulum (ER)-associated degradation (ERAD), which orchestrates the clearance of structurally aberrant proteins under basal conditions, is boosted by the unfolded protein response (UPR) as one of several means to relieve ER stress. However, the underlying mechanism that links the two systems in higher eukaryotes has remained elusive. Herein, the results of transient expression, RNAi-mediated knockdown and functional studies demonstrate that the transcriptional elevation of EDEM1 boosts the efficiency of glycoprotein ERAD through the formation of
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available