Journal
JOURNAL OF CELL BIOLOGY
Volume 217, Issue 10, Pages 3330-3342Publisher
ROCKEFELLER UNIV PRESS
DOI: 10.1083/jcb.201804052
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Funding
- National Institutes of Health [R01 EB014869, R01 GM099481, R01 AR068636]
- National Science Foundation
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Positioning and shaping the nucleus represents a mechanical challenge for the migrating cell because of its large size and resistance to deformation. Cells shape and position the nucleus by transmitting forces from the cytoskeleton onto the nuclear surface. This force transfer can occur through specialized linkages between the nuclear envelope and the cytoskeleton. In response, the nucleus can deform and/or it can move. Nuclear movement will occur when there is a net differential in mechanical force across the nucleus, while nuclear deformation will occur when mechanical forces overcome the mechanical resistance of the various structures that comprise the nucleus. In this perspective, we review current literature on the sources and magnitude of cellular forces exerted on the nucleus, the nuclear envelope proteins involved in transferring cellular forces, and the contribution of different nuclear structural components to the mechanical response of the nucleus to these forces.
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