Journal
JOURNAL OF CELL BIOLOGY
Volume 207, Issue 4, Pages 441-451Publisher
ROCKEFELLER UNIV PRESS
DOI: 10.1083/jcb.201407015
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Funding
- National Institutes of Health [DK075555, DK095811]
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Epithelial cells from diverse tissues, including the enterocytes that line the intestinal tract, remodel their apical surface during differentiation to form a brush border: an array of actin-supported membrane protrusions known as microvilli that increases the functional capacity of the tissue. Although our understanding of how epithelial cells assemble, stabilize, and organize apical microvilli is still developing, investigations of the biochemical and physical underpinnings of these processes suggest that cells coordinate cytoskeletal remodeling, membrane-cytoskeleton cross-linking, and extracellular adhesion to shape the apical brush border domain.
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