Journal
JOURNAL OF CELL BIOLOGY
Volume 204, Issue 3, Pages 331-342Publisher
ROCKEFELLER UNIV PRESS
DOI: 10.1083/jcb.201310136
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Funding
- Swiss National Science Foundation
- Kanton Basel-Stadt
- Uehara Memorial Foundation
- KANAE Foundation for the Promotion of Medical Science
- Astellas Foundation for Research on Metabolic Disorders
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The unique functional properties and molecular identity of neuronal cell populations rely on cell type-specific gene expression programs. Alternative splicing represents a powerful mechanism for expanding the capacity of genomes to generate molecular diversity. Neuronal cells exhibit particularly extensive alternative splicing regulation. We report a highly selective expression of the KH domain-containing splicing regulators SLM1 and SLM2 in the mouse brain. Conditional ablation of SLM1 resulted in a severe defect in the neuronal isoform content of the polymorphic synaptic receptors neurexin-1, -2, and -3. Thus, cell type-specific expression of SLM1 provides a mechanism for shaping the molecular repertoires of synaptic adhesion molecules in neuronal populations in vivo.
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