Journal
JOURNAL OF CELL BIOLOGY
Volume 205, Issue 5, Pages 621-631Publisher
ROCKEFELLER UNIV PRESS
DOI: 10.1083/jcb.201401050
Keywords
-
Categories
Funding
- UCSF Sandler Asthma Basic Research Center
- National Institutes of Health [Al1077439, HL53949, HL099101, HL102292, HL108596]
Ask authors/readers for more resources
The clinical manifestations of asthma are caused by obstruction of the conducting airways of the lung. Two airway cell types are critical for asthma pathogenesis: epithelial cells and smooth muscle cells. Airway epithelial cells, which are the first line of defense against inhaled pathogens and particles, initiate airway inflammation and produce mucus, an important contributor to airway obstruction. The other main cause of airway obstruction is contraction of airway smooth muscle. Complementary experimental approaches involving cultured cells, animal models, and human clinical studies have provided many insights into diverse mechanisms that contribute to airway epithelial and smooth muscle cell pathology in this complex disease.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available