Journal
JOURNAL OF CELL BIOLOGY
Volume 206, Issue 5, Pages 671-688Publisher
ROCKEFELLER UNIV PRESS
DOI: 10.1083/jcb.201401072
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Funding
- Wellcome Trust [092927/Z/10/Z]
- Oxford Cancer Research Centre (OCRC
- Cancer Research UK clinical training fund)
- Cancer Research UK [C38302/Al2278]
- Biotechnology and Biological Sciences Research Council [BB/K017462/1]
- Medical Research Council studentship
- The British Province of the Society of Jesus [626791]
- Biotechnology and Biological Sciences Research Council [BB/K017462/1] Funding Source: researchfish
- Medical Research Council [1252459] Funding Source: researchfish
- National Institute for Health Research [NF-SI-0509-10242] Funding Source: researchfish
- BBSRC [BB/K017462/1] Funding Source: UKRI
- Wellcome Trust [092927/Z/10/Z] Funding Source: Wellcome Trust
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Male reproductive glands secrete signals into seminal fluid to facilitate reproductive success. In Drosophila melanogaster, these signals are generated by a variety of seminal peptides, many produced by the accessory glands (AGs). One epithelial cell type in the adult male AGs, the secondary cell (SC), grows selectively in response to bone morphogenetic protein (BMP) signaling. This signaling is involved in blocking the rapid remating of mated females, which contributes to the reproductive advantage of the first male to mate. In this paper, we show that SCs secrete exosomes, membrane-bound vesicles generated inside late endosomal multivesicular bodies (MVBs). After mating, exosomes fuse with sperm (as also seen in vitro for human prostate-derived exosomes and sperm) and interact with female reproductive tract epithelia. Exosome release was required to inhibit female remating behavior, suggesting that exosomes are downstream effectors of BMP signaling. Indeed, when BMP signaling was reduced in SCs, vesicles were still formed in MVBs but not secreted as exosomes. These results demonstrate a new function for the MVB-exosome pathway in the reproductive tract that appears to be conserved across evolution.
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