Journal
JOURNAL OF CELL BIOLOGY
Volume 201, Issue 6, Pages 785-796Publisher
ROCKEFELLER UNIV PRESS
DOI: 10.1083/jcb.201304054
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Funding
- American Heart Association Postdoctoral Fellowship [13POST13930019]
- Machlus and National Institutes of Health National Heart, Lung, and Blood Institute [R01 HL68130]
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Circulating blood platelets are specialized cells that prevent bleeding and minimize blood vessel injury. Large progenitor cells in the bone marrow called megakaryocytes (MKs) are the source of platelets. MKs release platelets through a series of fascinating cell biological events. During maturation, they become polyploid and accumulate massive amounts of protein and membrane. Then, in a cytoskeletal-driven process, they extend long branching processes, designated proplatelets, into sinusoidal blood vessels where they undergo fission to release platelets. Given the need for platelets in many pathological situations, understanding how this process occurs is an active area of research with important clinical applications.
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