Journal
JOURNAL OF CELL BIOLOGY
Volume 203, Issue 2, Pages 187-196Publisher
ROCKEFELLER UNIV PRESS
DOI: 10.1083/jcb.201304047
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Funding
- Canadian Institutes of Health Research [MOP 36519, MOP 106502]
- Alberta Innovates Health Solutions, Howard Hughes Medical Institute
- Li Ka Shing Institute of Virology at the University of Alberta
- Uehara Memorial Foundation
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In the yeast Saccharomyces cerevisiae, organelles and macromolecular complexes are delivered from the mother to the emerging daughter during cell division, thereby ensuring progeny viability. Here, we have shown that during mitosis nuclear pore complexes (NPCs) in the mother nucleus are actively delivered through the bud neck and into the daughter cell concomitantly with the nuclear envelope. Furthermore, we show that NPC movement into the daughter cell requires members of an NPC subcomplex containing Nsp1p and its interacting partners. NPCs lacking these nucleoporins (Nups) were blocked from entry into the daughter by a putative barrier at the bud neck. This selection process could be observed within individual cells such that NPCs containing Nup82p (an Nsp1p-interacting Nup) were transferred to the daughter cells while functionally compromised NPCs lacking Nup82p were retained in the mother. This mechanism is proposed to facilitate the inheritance of functional NPCs by daughter cells.
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