Journal
JOURNAL OF CELL BIOLOGY
Volume 202, Issue 1, Pages 11-13Publisher
ROCKEFELLER UNIV PRESS
DOI: 10.1083/jcb.201305155
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Cellular senescence is a state of irreversible cell cycle arrest that has been documented to both suppress cancer and promote aging. Although not well understood, extensive nuclear changes, including the remodeling of chromatin, take place as cells become senescent. In this issue, Ivanov et al. (2013. J. Cell Biol. http://dx.doi.org/jcb.201212110) report that chromatin fragments are released from the nuclei of senescent cells and are subsequently targeted for processing through the autophagy/lysosomal pathway.
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