Journal
JOURNAL OF CELL BIOLOGY
Volume 201, Issue 7, Pages 969-979Publisher
ROCKEFELLER UNIV PRESS
DOI: 10.1083/jcb.201212130
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Funding
- National Institutes of Health, National Institute of Dental and Craniofacial Research
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Time-lapse fluorescence microscopy is one of the main tools used to image subcellular structures in living cells. Yet for decades it has been applied primarily to in vitro model systems. Thanks to the most recent advancements in intravital microscopy, this approach has finally been extended to live rodents. This represents a major breakthrough that will provide unprecedented new opportunities to study mammalian cell biology in vivo and has already provided new insight in the fields of neurobiology, immunology, and cancer biology.
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