Journal
JOURNAL OF CELL BIOLOGY
Volume 203, Issue 6, Pages 875-881Publisher
ROCKEFELLER UNIV PRESS
DOI: 10.1083/jcb.201308087
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Funding
- National Institutes of Health New Innovator Award [DP2GM105437-01]
- Searle Scholar Award
- National Science Foundation CAREER Award [PHY-1253035]
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The coordinated growth of cells and their organelles is a fundamental and poorly understood problem, with implications for processes ranging from embryonic development to oncogenesis. Recent experiments have shed light on the cell size-dependent assembly of membrane-less cytoplasmic and nucleoplasmic structures, including ribonucleoprotein (RNP) granules and other intracellular bodies. Many of these structures behave as condensed liquid-like phases of the cytoplasm/nucleoplasm. The phase transitions that appear to govern their assembly exhibit an intrinsic dependence on cell size, and may explain the size scaling reported for a number of structures. This size scaling could, in turn, play a role in cell growth and size control.
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