Journal
JOURNAL OF CELL BIOLOGY
Volume 196, Issue 3, Pages 305-313Publisher
ROCKEFELLER UNIV PRESS
DOI: 10.1083/jcb.201102078
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Funding
- Eidgenossische Technische Hochschule Zurich
- Swiss National Foundation
- European Research Council
- Institut des Hautes Etudes Scientifiques
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Studies on cell division traditionally focus on the mechanisms of chromosome segregation and cytokinesis, yet we know comparatively little about how organelles segregate. Analysis of organelle partitioning in asymmetrically dividing cells has provided insights into the mechanisms through which cells control organelle distribution. Interestingly, these studies have revealed that segregation mechanisms frequently link organelle distribution to organelle growth and formation. Furthermore, in many cases, cells use organelles, such as the endoplasmic reticulum and P granules, as vectors for the segregation of information. Together, these emerging data suggest that the coordination between organelle growth, division, and segregation plays an important role in the control of cell fate inheritance, cellular aging, and rejuvenation, i.e., the resetting of age in immortal lineages.
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