Journal
JOURNAL OF CELL BIOLOGY
Volume 198, Issue 6, Pages 961-971Publisher
ROCKEFELLER UNIV PRESS
DOI: 10.1083/jcb.201206112
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Funding
- MacArthur Foundation
- Australian Research Council Future Fellowship [FT100100112]
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Malaria is a major disease of humans caused by protozoan parasites from the genus Plasmodium. It has a complex life cycle; however, asexual parasite infection within the blood stream is responsible for all disease pathology. This stage is initiated when merozoites, the free invasive blood-stage form, invade circulating erythrocytes. Although invasion is rapid, it is the only time of the life cycle when the parasite is directly exposed to the host immune system. Significant effort has, therefore, focused on identifying the proteins involved and understanding the underlying mechanisms behind merozoite invasion into the protected niche inside the human erythrocyte.
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