Journal
JOURNAL OF CELL BIOLOGY
Volume 199, Issue 6, Pages 871-881Publisher
ROCKEFELLER UNIV PRESS
DOI: 10.1083/jcb.201210040
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Funding
- National Cancer Institute [K99CA154531-01]
- Howard Hughes Medical Institute
- National Institutes of Health
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Cellular defects that impair the fidelity of mitosis promote chromosome missegregation and aneuploidy. Increasing evidence reveals that errors in mitosis can also promote the direct and indirect acquisition of DNA damage and chromosome breaks. Consequently, deregulated cell division can devastate the integrity of the normal genome and unleash a variety of oncogenic stimuli that may promote transformation. Recent work has shed light on the mechanisms that link abnormal mitosis with the development of DNA damage, how cells respond to such affronts, and the potential impact on tumorigenesis.
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