Journal
JOURNAL OF CELL BIOLOGY
Volume 196, Issue 5, Pages 605-621Publisher
ROCKEFELLER UNIV PRESS
DOI: 10.1083/jcb.201107137
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Funding
- National Cancer Institute [T32CA078207]
- Mlodzik laboratory
- National Institutes of Health [GM62917]
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Cellular morphogenesis, including polarized out-growth, promotes tissue shape and function. Polarized vesicle trafficking has emerged as a fundamental mechanism by which protein and membrane can be targeted to discrete subcellular domains to promote localized protrusions. Frizzled (Fz)/planar cell polarity (PCP) signaling orchestrates cytoskeletal polarization and drives morphogenetic changes in such contexts as the vertebrate body axis and external Drosophila melanogaster tissues. Although regulation of Fz/PCP signaling via vesicle trafficking has been identified, the interplay between the vesicle trafficking machinery and downstream terminal PCP-directed processes is less established. In this paper, we show that Drosophila CK1-gamma/gilgamesh (gish) regulates the PCP-associated process of trichome formation through effects on Rab11-mediated vesicle recycling. Although the core Fz/PCP proteins dictate prehair formation broadly, CK1-gamma/gish restricts nucleation to a single site. Moreover, CK1-gamma/gish works in parallel with the Fz/PCP effector multiple wing hairs, which restricts prehair formation along the perpendicular axis to Gish. Our findings suggest that polarized Rab11-mediated vesicle trafficking regulated by CK1-gamma is required for PCP-directed processes.
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