Journal
JOURNAL OF CELL BIOLOGY
Volume 199, Issue 2, Pages 205-209Publisher
ROCKEFELLER UNIV PRESS
DOI: 10.1083/jcb.201207019
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Funding
- AMC
- Ecole Polytechnique Federale de Lausanne
- EU [ERC-2008-AdG-23118]
- Velux Stiftung
- Swiss National Science Foundation [31003A-124713, CRSII3-136201]
- Swiss National Science Foundation (SNF) [31003A_124713, CRSII3_136201] Funding Source: Swiss National Science Foundation (SNF)
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NAD(+) is a central metabolite in the cell. Changes in NAD(+) abundance and the activity of NAD(+)-dependent enzymes, such as the sirtuins, are at the core of metabolic/mitochondrial diseases, such as obesity and diabetes, and of cancer and neurodegeneration. Here, we discuss how maintaining or raising NAD(+) levels can improve metabolism and prevent age-related functional decline and associated disease, and how basic scientific discoveries in the NAD(+) signaling pathway are being translated to the clinic.
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