Journal
NEUROGASTROENTEROLOGY AND MOTILITY
Volume 27, Issue 4, Pages 559-568Publisher
WILEY
DOI: 10.1111/nmo.12532
Keywords
acupoint specificity; cerebral activity; functional dyspepsia
Funding
- National Basic Research Program of China (973 Program) [2012CB518501]
- Youth Foundation of National Natural Science Foundation of China [81001504]
- New Century Outstanding Talents Support Program of Education Ministry of China
- Youth Foundation of Sichuan Province [2012JQ0052]
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Background To investigate the similarities and differences in cerebral responses to puncturing at different acupoints for treating meal-related functional dyspepsia (FD). Methods Twenty right-handed FD patients were enrolled and randomized divided into two groups. Each patient received 20 sessions' electroacupuncture treatment. The acupoints used in Group A were four acupoints on the Stomach Meridian, and the acupoints used in Group B were four acupoints on the Gallbladder Meridian. PET-CT scans were performed before and after acupuncture treatment to record the changes of cerebral glycometabolism. Key Results After treatment, the dyspepsia symptoms and the quality of life (QOL) of the patients in each group were significantly improved (p < 0.05) and there was insignificant difference in efficacy between the two groups (p > 0.05). In Group A, deactivation in brainstem, bilateral anterior cingulate cortex (ACC) and cerebellum, left superior medial frontal gyrus, orbital frontal cortex (OFC), and thalamus, etc., and activation in bilateral middle cingulate cortex (MCC), precuneus and lingual gyrus, etc. were observed. In Group B, deactivation in brainstem, bilateral thalamus, putamen, ACC, postterior cingulate cortex, hippocampus and cerebellum, etc., and activation in bilateral MCC, precuneus, left OFC, etc. were observed (p < 0.05, Family-wise error corrected). Conclusions & Inferences Different acupoints have similar clinical efficacy but relatively different cerebral responses. The influence on the sensory transduction regions (brainstem and thalamus) and visceral modulation regions might be the common mechanism of different acupoints treating for FD, and the modulation on some emotion/cognition-related areas (e.g., prefrontal cortex) is the potential difference between the different acupoints.
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