Journal
JOURNAL OF CELL BIOLOGY
Volume 198, Issue 3, Pages 277-279Publisher
ROCKEFELLER UNIV PRESS
DOI: 10.1083/jcb.201207076
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BiP is the predominant DnaK/Hsp70-type chaperone protein in the ER. It is required for folding and assembling newly synthesized ER client proteins, yet having too much BiP inhibits folding. In this issue, Chambers et al. (2012. J. Cell Biol. doi:10.1083/jcb.201202005) report that ADP ribosylation of BiP provides a reversible switch that fine tunes BiP activity according to need.
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