Journal
JOURNAL OF CELL BIOLOGY
Volume 198, Issue 1, Pages 7-10Publisher
ROCKEFELLER UNIV PRESS
DOI: 10.1083/jcb.201206003
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Funding
- NIA NIH HHS [R01AG030746, R01 AG030746] Funding Source: Medline
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Mutations in presenilins (PS), transmembrane proteins encoding the catalytic subunit of gamma-secretase, result in familial Alzheimer's disease (FAD). Several studies have identified lysosomal defects in cells lacking PS or expressing FAD-associated PS mutations, which have been previously attributed to a function for PS in lysosomal acidification. Now, in this issue, Coen et al. (2012. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201201076) provide a series of results that challenge this idea and propose instead that presenilins play a role in calcium-mediated lysosomal fusion.
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