Journal
JOURNAL OF CELL BIOLOGY
Volume 192, Issue 1, Pages 7-16Publisher
ROCKEFELLER UNIV PRESS
DOI: 10.1083/jcb.201006159
Keywords
-
Categories
Funding
- National Institutes of Health [5R37-GM32453]
- Deutsche Forschungsgemeinschaft [SFB635]
- European Research Council [ERC-AdG-233078]
Ask authors/readers for more resources
Mitochondria are dynamic organelles whose functional integrity requires a coordinated supply of proteins and phospholipids. Defined functions of specific phospholipids, like the mitochondrial signature lipid cardiolipin, are emerging in diverse processes, ranging from protein biogenesis and energy production to membrane fusion and apoptosis. The accumulation of phospholipids within mitochondria depends on interorganellar lipid transport between the endoplasmic reticulum (ER) and mitochondria as well as intramitochondrial lipid trafficking. The discovery of proteins that regulate mitochondrial membrane lipid composition and of a multiprotein complex tethering ER to mitochondrial membranes has unveiled novel mechanisms of mitochondrial membrane biogenesis.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available