Journal
JOURNAL OF CELL BIOLOGY
Volume 195, Issue 7, Pages 1083-1092Publisher
ROCKEFELLER UNIV PRESS
DOI: 10.1083/jcb.201107132
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Funding
- National Institutes of Health, National Institute for Allergy and Infectious Disease [R01-AI056404, R01-AI087808]
- Welch Foundation [I-1561]
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Bacterial pathogens use effector proteins to manipulate their hosts to propagate infection. These effectors divert host cell signaling pathways to the benefit of the pathogen and frequently target kinase signaling cascades. Notable pathways that are usurped include the nuclear factor kappa B (NF-kappa B), mitogen-activated protein kinase (MAPK), phosphatidylinositol 3-kinase (PI3K)/Akt, and p21-activated kinase (PAK) pathways. Analyzing the functions of pathogenic effectors and their intersection with host kinase pathways has provided interesting insights into both the mechanisms of virulence and eukaryotic signaling.
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