Journal
JOURNAL OF CELL BIOLOGY
Volume 194, Issue 2, Pages 335-346Publisher
ROCKEFELLER UNIV PRESS
DOI: 10.1083/jcb.201012157
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Funding
- Fonds National Suisse de la Recherche Scientifique [310030-124910]
- Fondation Suisse de Recherche sur les Maladies Musculaires
- Fondation Hans Wilsdorf
- Fondation Marcel Levaillant
- Swiss National Science Foundation (SNF) [310030_124910] Funding Source: Swiss National Science Foundation (SNF)
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Cytosolic Ca2+ signals encoded by repetitive Ca2+ releases rely on two processes to refill Ca2+ stores: Ca2+ reuptake from the cytosol and activation of a Ca2+ influx via store-operated Ca2+ entry (SOCE). However, SOCE activation is a slow process. It is delayed by >30 s after store depletion because stromal interaction molecule 1 (STIM1), the Ca2+ sensor of the intracellular stores, must form clusters and migrate to the membrane before being able to open Orai1, the plasma membrane Ca2+ channel. In this paper, we identify a new protein, STIM1L, that colocalizes with Orai1 Ca2+ channels and interacts with actin to form permanent clusters. This property allowed the immediate activation of SOCE, a characteristic required for generating repetitive Ca2+ signals with frequencies within seconds such as those frequently observed in excitable cells. STIM1L was expressed in several mammalian tissues, suggesting that many cell types rely on this Ca2+ sensor for their Ca2+ homeostasis and intracellular signaling.
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