Journal
JOURNAL OF CELL BIOLOGY
Volume 193, Issue 6, Pages 963-972Publisher
ROCKEFELLER UNIV PRESS
DOI: 10.1083/jcb.201102042
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Funding
- Wellcome Trust
- Medical Research Council (UK)
- National Institutes of Health (Bethesda, MD)
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Tremendous variety in form and function is displayed among the intracellular membrane systems of different eukaryotes. Until recently, few clues existed as to how these internal membrane systems had originated and diversified. However, proteomic, structural, and comparative genomics studies together have revealed extensive similarities among many of the protein complexes used in controlling the morphology and trafficking of intracellular membranes. These new insights have had a profound impact on our understanding of the evolutionary origins of the internal architecture of the eukaryotic cell.
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