Journal
JOURNAL OF CELL BIOLOGY
Volume 195, Issue 1, Pages 99-112Publisher
ROCKEFELLER UNIV PRESS
DOI: 10.1083/jcb.201106048
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Funding
- Canadian Institutes for Health Research [MOP-89877]
- Association pour la Recherche contre le Cancer [3832, 1111]
- Fondation pour la Recherche Medicale
- Agence Nationale de la Recherche
- Ministere de la Recherche et de l'Education Superieure
- fondation Lavoisier
- European Molecular Biology Organization
- Association pour la Recherche contre le Cancer
- Canadian Cancer Society [018450, 019162]
- Terry Fox Foundation
- Canadian Center of Excellence in Commercialization and Research
- Canada Foundation for Innovation
- Fonds de Recherche en Sante du Quebec
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The cortical mechanisms that drive the series of mitotic cell shape transformations remain elusive. In this paper, we identify two novel networks that collectively control the dynamic reorganization of the mitotic cortex. We demonstrate that Moesin, an actin/membrane linker, integrates these two networks to synergize the cortical forces that drive mitotic cell shape transformations. We find that the Pp1-87B phosphatase restricts high Moesin activity to early mitosis and down-regulates Moesin at the polar cortex, after anaphase onset. Overactivation of Moesin at the polar cortex impairs cell elongation and thus cytokinesis, whereas a transient recruitment of Moesin is required to retract polar blebs that allow cortical relaxation and dissipation of intracellular pressure. This fine balance of Moesin activity is further adjusted by Skittles and Pten, two enzymes that locally produce phosphoinositol 4,5-bisphosphate and thereby, regulate Moesin cortical association. These complementary pathways provide a spatiotemporal framework to explain how the cell cortex is remodeled throughout cell division.
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