Journal
JOURNAL OF CELL BIOLOGY
Volume 192, Issue 5, Pages 723-733Publisher
ROCKEFELLER UNIV PRESS
DOI: 10.1083/jcb.201010058
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Funding
- Centre National de la Recherche Scientifique, Institut Pasteur
- Agence Nationale de la Recherche Programme Interdisciplinaire de Recherches sur les Systemes Moleculaires et Cellulaires, et d'innovation Biomedicale (ANR-PIRIBIO) [ANR-09-PIRI-0024]
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-The spatial organization of genes and chromosomes plays an important role in the regulation of several DNA processes. However, the principles and forces underlying this nonrandom organization are mostly unknown. Despite its small dimension, and thanks to new imaging and biochemical techniques, studies of the budding yeast nucleus have led to significant insights into chromosome arrangement and dynamics. The dynamic organization of the yeast genome during interphase argues for both the physical properties of the chromatin fiber and specific molecular interactions as drivers of nuclear order.
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