Journal
JOURNAL OF CELL BIOLOGY
Volume 193, Issue 4, Pages 607-618Publisher
ROCKEFELLER UNIV PRESS
DOI: 10.1083/jcb.201012094
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Funding
- Swiss National Science Foundation [PPP0033-114898]
- Medic Foundation
- Telethon Foundation
- Emma Muschamp Foundation
- National Center of Competence in Research Molecular Oncology
- Oncosuisse
- Swiss Cancer League
- Association for International Cancer Research
- Royal Netherlands Academy of Arts and Sciences
- Wageningen University and Research Centre
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The lymphatic vasculature constitutes a highly specialized part of the vascular system that is essential for the maintenance of interstitial fluid balance, uptake of dietary fat, and immune response. Recently, there has been an increased awareness of the importance of lymphatic vessels in many common pathological conditions, such as tumor cell dissemination and chronic inflammation. Studies of embryonic development and genetically engineered animal models coupled with the discovery of mutations underlying human lymphedema syndromes have contributed to our understanding of mechanisms regulating normal and pathological lymphatic morphogenesis. It is now crucial to use this knowledge for the development of novel therapies for human diseases.
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