Journal
JOURNAL OF CELL BIOLOGY
Volume 189, Issue 4, Pages 619-629Publisher
ROCKEFELLER UNIV PRESS
DOI: 10.1083/jcb.201003008
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Funding
- Finish Academy [SA 1125867]
- Netherlands Organization for Scientific Research
- Netherlands Organization for Health Research and Development
- European Science Foundation
- EMBO
- Human Frontier Science Program Career Development Award (HFSP-CDA)
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Dendritic spines are small actin-rich protrusions from neuronal dendrites that form the postsynaptic part of most excitatory synapses and are major sites of information processing and storage in the brain. Changes in the shape and size of dendritic spines are correlated with the strength of excitatory synaptic connections and heavily depend on remodeling of its underlying actin cytoskeleton. Emerging evidence suggests that most signaling pathways linking synaptic activity to spine morphology influence local actin dynamics. Therefore, specific mechanisms of actin regulation are integral to the formation, maturation, and plasticity of dendritic spines and to learning and memory.
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