Journal
JOURNAL OF CELL BIOLOGY
Volume 189, Issue 6, Pages 925-935Publisher
ROCKEFELLER UNIV PRESS
DOI: 10.1083/jcb.201002021
Keywords
-
Categories
Ask authors/readers for more resources
Pattern recognition receptors detect microbial components and induce innate immune responses, the first line of host defense against infectious agents. However, aberrant activation of immune responses often causes massive inflammation, leading to the development of autoimmune diseases. Therefore, both activation and inactivation of innate immune responses must be strictly controlled. Recent studies have shown that the cellular machinery associated with protein degradation, such as autophagy, is important for the regulation of innate immunity. These studies reveal that autophagy-related proteins are involved in the innate immune response and may contribute to the development of inflammatory disorders.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available