Journal
JOURNAL OF CELL BIOLOGY
Volume 191, Issue 4, Pages 701-710Publisher
ROCKEFELLER UNIV PRESS
DOI: 10.1083/jcb.201006173
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Funding
- National Science Foundatio
- National Institutes of Health [DK57328]
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Polycystic kidney disease is a common genetic disorder in which fluid-filled cysts displace normal renal tubules Here we focus on autosomal dominant polycystic kidney disease, which is attributable to mutations in the PKD1 and PKD2 genes and which is characterized by perturbations of renal epithelial cell growth control, fluid transport, and morphogenesis The mechanisms that connect the under lying genetic defects to disease pathogenesis are poorly understood, but their exploration is shedding new light on interesting cell biological processes and suggesting novel therapeutic targets
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