Journal
JOURNAL OF CELL BIOLOGY
Volume 190, Issue 5, Pages 793-805Publisher
ROCKEFELLER UNIV PRESS
DOI: 10.1083/jcb.201002055
Keywords
-
Categories
Funding
- National Institutes of Health [GM058406-12]
- Ministry of Education, Science and Culture of Japan [20380063, 21780097]
- Grants-in-Aid for Scientific Research [21780097, 20380063] Funding Source: KAKEN
Ask authors/readers for more resources
The mechanisms that regulate cytoskeletal remodeling during the transition between mitosis and interphase are poorly understood. In fission yeast the MOR pathway promotes actin polarization to cell tips in interphase, whereas the SIN signaling pathway drives actomyosin ring assembly and cytokinesis. We show that the SIN inhibits MOR signaling in mitosis by interfering with Nak1 kinase-mediated activation of the most downstream MOR component, the NDR family kinase Orb6. Inactivation of the MOR may be a key function of the SIN because attenuation of MOR signaling rescued the cytokinetic defects of SIN mutants and allowed weak SIN signaling to trigger ectopic cytokinesis. Furthermore, failure to inhibit the MOR is toxic when the cell division apparatus is compromised. Together, our results reveal a mutually antagonistic relationship between the SIN and MOR pathways, which is important for completion of cytokinesis and coordination of cytoskeletal remodeling at the mitosis-to-interphase transition.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available