Journal
JOURNAL OF CELL BIOLOGY
Volume 188, Issue 5, Pages 621-628Publisher
ROCKEFELLER UNIV PRESS
DOI: 10.1083/jcb.200910001
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Funding
- Italian Association for Cancer Research (Milan, Italy) [IG 6074]
- Telethon (Italy)
- University of California Cancer Research Coordinating Committee
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The mammalian Golgi apparatus is characterized by a ribbon-like organization adjacent to the centrosome during interphase and extensive fragmentation and dispersal away from the centrosome during mitosis. It is not clear whether this dynamic association between the Golgi and centrosome is of functional significance. We discuss recent findings indicating that the Golgi-centrosome relationship may be important for directional protein transport and centrosome positioning, which are both required for cell polarization. We also summarize our current knowledge of the link between Golgi organization and cell cycle progression.
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