Journal
JOURNAL OF CELL BIOLOGY
Volume 191, Issue 3, Pages 453-462Publisher
ROCKEFELLER UNIV PRESS
DOI: 10.1083/jcb.201007136
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Funding
- Ministry of Education Culture Sports Science and Technology of Japan
- Takeda Science Foundation
- Grants-in-Aid for Scientific Research [21227004] Funding Source: KAKEN
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The actin cytoskeleton undergoes rapid changes in its architecture during mitosis Here, we demonstrate novel actin assembly dynamics in M phase An amorphous cluster of actin filaments appears during pro metaphase, revolves horizontally along the cell cortex at a constant angular speed, and fuses into the contractile ring after three to four revolutions Cdk1 activity is required for the formation of this mitotic actin cluster and its revolving movement Rapid turnover of actin in the filaments takes place everywhere in the cluster and is also required for its cluster rotation during mitosis Knockdown of Arp3, a component of the actin filament nucleating Arp2/3 complex, inhibits the formation of the mitotic actin cluster without affecting other actin structures These results identify Arp2/3 complex as a key factor in the generation of the dynamic actin cluster during mitosis
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