Journal
JOURNAL OF CELL BIOLOGY
Volume 189, Issue 7, Pages 1075-1077Publisher
ROCKEFELLER UNIV PRESS
DOI: 10.1083/jcb.201005151
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Cell-cell adhesions are sites where cells experience and resist tugging forces. It has long been postulated, but not directly tested, that cadherin adhesion molecules may serve in mechanotransduction at cell-cell contacts. In this issue, Le Duc et al. (2010. J. Cell Biol. doi: 10.1083/jcb.201001149) provide direct evidence that E-cadherin participates in a mechanosensing pathway that regulates the actomyosin cytoskeleton to modulate cell stiffness in response to pulling force.
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