Journal
JOURNAL OF CELL BIOLOGY
Volume 187, Issue 3, Pages 319-326Publisher
ROCKEFELLER UNIV PRESS
DOI: 10.1083/jcb.200908074
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Funding
- National Cancer Institute [1K08CA106597-01]
- American Cancer Society Research Scholar Grant
- Sidney Kimmel Foundation Scholar Award
- Mary Kay Ash Foundation Translational Innovation Award
- Abramson Family Cancer Research Institute
- Center of Excellence in Environmental Toxicology
- University Research Foundation of the University of Pennsylvania
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The intimate relationship between DNA double-strand break (DSB) repair and cancer susceptibility has sparked profound interest in how transactions on DNA and chromatin surrounding DNA damage influence genome integrity. Recent evidence implicates a substantial commitment of the cellular DNA damage response machinery to the synthesis, recognition, and hydrolysis of ubiquitin chains at DNA damage sites. In this review, we propose that, in order to accommodate parallel processes involved in DSB repair and checkpoint signaling, DSB-associated ubiquitin structures must be nonuniform, using different linkages for distinct functional outputs. We highlight recent advances in the study of nondegradative ubiquitin signaling at DSBs, and discuss how recognition of different ubiquitin structures may influence DNA damage responses.
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