Journal
JOURNAL OF CELL BIOLOGY
Volume 184, Issue 3, Pages 355-356Publisher
ROCKEFELLER UNIV PRESS
DOI: 10.1083/jcb.200812016
Keywords
-
Categories
Ask authors/readers for more resources
Eukaryotic cells have evolved a spindle assembly checkpoint (SAC) that facilitates accurate genomic segregation during mitosis by delaying anaphase onset in response to errors in kinetochore microtubule attachment. In contrast to the well-studied molecular mechanism by which the SAC blocks anaphase onset, the events triggering SAC release are poorly understood. Papers in this issue by Uchida et al. (Uchida, K. S. K., K. Takagaki, K. Kumada, Y. Hirayama, T. Noda, and T. Hirota. 2009. J. Cell Biol. 184: 383-390) and Maresca and Salmon (Maresca, T. J., and E. D. Salmon. 2009. J. Cell Biol. 184: 373-381) make an important advance by demonstrating that SAC release depends on molecular rearrangements within the kinetochore rather than tension-produced stretch between sister kinetochores.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available