Journal
JOURNAL OF CELL BIOLOGY
Volume 183, Issue 4, Pages 583-587Publisher
ROCKEFELLER UNIV PRESS
DOI: 10.1083/jcb.200806149
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Funding
- National Science Foundation [DMR-0602684, CTS-0505929]
- Harvard Materials Research Science and Engineering Center [DMR-0820484]
- Harvard Interdisciplinary Graduate Education and Research Training program on Biomechanics [DGE-0221682]
- Foundation for Fundamental Research on Matter (FOM)
- European Marie Curie Fellowship [8526]
- Direct For Mathematical & Physical Scien
- Division Of Materials Research [820484] Funding Source: National Science Foundation
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Random motion within the cytoplasm gives rise to molecular diffusion; this motion is essential to many biological processes. However, in addition to thermal Brownian motion, the cytoplasm also undergoes constant agitation caused by the activity of molecular motors and other nonequilibrium cellular processes. Here, we discuss recent work that suggests this activity can give rise to cytoplasmic motion that has the appearance of diffusion but is significantly enhanced in its magnitude and which can play an important biological role, particularly in cytoskeletal assembly.
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