Journal
JOURNAL OF CELL BIOLOGY
Volume 180, Issue 1, Pages 23-29Publisher
ROCKEFELLER UNIV PRESS
DOI: 10.1083/jcb.200709133
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Funding
- NIGMS NIH HHS [R01 GM050718, GM50718] Funding Source: Medline
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Intraflagellar transport (IFT), the motor-dependent movement of IFT particles along the axoneme, is critical for the assembly, maintenance, and function of motile and sensory cilia, and, consequently, this process underlies ciliary motility, cilium-based signaling, and ciliopathies. Here, I present my perspective on IFT as a model system for studying motor-driven cargo transport. I review evidence that kinesin-2 motors physically transport IFT particles as cargo and hypothesize that several accessory kinesins confer cilia-specific functions by augmenting the action of the two core IFT motors, kinesin-2 and dynein 1b, which assemble the cilium foundation.
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