Journal
JOURNAL OF CELL BIOLOGY
Volume 180, Issue 5, Pages 853-855Publisher
ROCKEFELLER UNIV PRESS
DOI: 10.1083/jcb.200802062
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Funding
- NIGMS NIH HHS [R01 GM083035, GM083035] Funding Source: Medline
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The actin-related protein 2/3 (Arp2/3) story has captivated the cytoskeleton community for over a decade. Not only does this complex nucleate new actin. laments, but it also anchors them into a dendritic meshwork that is used in many cellular contexts such as lamellipodial protrusion, endosome rocketing, and the movement of pathogens. One key piece of this puzzle that has been missing is a detailed structure of the Arp2/3-actin branch. Using electron tomography and computational docking, Rouiller et al. (Rouiller, I., X.-P. Xu, K.J. Amann, C. Egile, S. Nickell, D. Nicastro, R. Li, T.D. Pollard, N. Volkmann, and D. Hanein. 2008. J. Cell Biol. 180:887-895) present an elegant and intriguing structure of the Arp2/3 complex-mediated actin branch.
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