Journal
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS
Volume 16, Issue 3-4, Pages 267-272Publisher
SAGE PUBLICATIONS INC
DOI: 10.1177/1074248411408313
Keywords
metabolic syndrome; ischemia-reperfusion injury; heart disease
Funding
- Intramural NIH HHS [ZIA HL002066-04, ZIA HL002065-04, ZIA HL006059-02, ZIA HL005102-07] Funding Source: Medline
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Cardioprotective strategies such as pre- and postconditioning result in a robust reduction in infarct size in young, healthy male animals. However, there are data suggesting that the protection is diminished in animals with comorbidities such as hypertension, hypercholesterolemia, and diabetes. It is important to understand at a mechanistic level the reasons for these differences. The effects of sex and diseases need to be considered in design of cardioprotective interventions in animal studies and clinical trials.
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