Journal
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
Volume 58, Issue 4, Pages 339-344Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/FJC.0b013e31821bc3f0
Keywords
adenylyl cyclase; A-kinase-anchoring protein; protein kinase A; G protein-coupled receptor; adrenergic receptor; phosphodiesterase
Funding
- NIH [GM060419]
- AHA [09GRNT2200034]
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3'-5'-Cyclic adenosine monophosphate (cAMP), generated by adenylyl cyclase (AC), serves as a second messenger in signaling pathways regulating many aspects of cardiac physiology, including contraction rate and action potential duration, and in the pathophysiology of hypertrophy and heart failure. A kinase-anchoring proteins localize the effect of cAMP in space and time by organizing receptors, AC, protein kinase A, and other components of the cAMP cascade into multiprotein complexes. In this review, we discuss how the interaction of A kinase-anchoring proteins with distinct AC isoforms affects cardiovascular physiology.
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