Journal
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
Volume 54, Issue 2, Pages 98-105Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/FJC.0b013e3181b2b6d4
Keywords
ion channels; chronic heart failure; angiotensin II; aldosterone; vasopressin; estrogens; arrhythmias; hormone receptors
Funding
- Swiss National Science Foundation [310030_ 120707]
- Ministry of Education, Science, Culture, Sports and Technology of Japan [19689006]
- Naito Foundation
- Swiss National Science Foundation (SNF) [310030_120707] Funding Source: Swiss National Science Foundation (SNF)
- Grants-in-Aid for Scientific Research [19689006] Funding Source: KAKEN
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Alteration of neurohormonal homeostasis is a hallmark of the pathophysiology of chronic heart failure (CHF). In particular, overactivation of the renin-angiotensin-aldosterone system and the sympathetic catecholaminergic system is consistently observed. Chronic overactivation of these hormonal pathways leads to a detrimental arrhythmogenic remodeling of cardiac tissue due to dysregulation of cardiac ion channels. Sudden cardiac death resulting from ventricular arrhythmias is a major cause of mortality in patients with CHF. All the drug classes known to reduce mortality in patients with CHF are neurohormonal blockers. The aim of this review was to provide an overview of how cardiac ion channels are regulated by hormones known to play a central role in the pathogenesis of CHF.
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