Journal
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
Volume 52, Issue 4, Pages 293-299Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/FJC.0b013e318171924d
Keywords
calcium handling; atrial fibrillation; remodeling; ryanodine; phospholamban
Funding
- German Federal Ministry of Education and Research [01Gi0204]
- Fondation Leducq
- Canadian Institutes of Health Research
- Quebec Heart and Stroke Foundation
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Atrial electrical and structural alterations (remodeling) have emerged as key elements in the development of the atrial fibrillation (AF) substrate. Evidence points to abnormalities in intracellular Ca2+ (calcium) handing as crucial links in AF-initiating focal activity and in perpetuation by rapidly firing foci and reentry. This review focuses on the molecular basis of altered Ca2+ handling in AF, with the goal of providing new insights into molecular effective antiarrhythmic therapy.
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