Journal
JOURNAL OF CARDIOLOGY
Volume 57, Issue 2, Pages 131-140Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jjcc.2011.01.002
Keywords
Atrial natriuretic peptide; Brain (B-type) natriuretic peptide; C-type natriuretic peptide; Heart failure
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Funding
- Ministry of Education, Culture, Sports, Science and Technology of Japan [18590787, 20590837]
- Promotion and Mutual Aid Corporation for Private Schools of Japan
- Japan Society for the Promotion of Science
- Japanese Ministry of Health, Labour and Welfare
- Grants-in-Aid for Scientific Research [23126511, 23591041, 18590787, 20590837] Funding Source: KAKEN
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The mammalian natriuretic peptide family consists of atrial (ANP), brain [B-type; BNP] and C-type natriuretic peptide (CNP) and three receptors, natriuretic receptors-A (NPRA), -B (NPR-B) and -C (NPR-C). Both ANP and BNP are abundantly expressed in the heart and are secreted mainly from the atria and ventricles, respectively. By contrast, CNP is mainly expressed in the central nervous system, bone and vasculature. Plasma concentrations of both ANP and BNP are elevated in patients with cardiovascular disease, though the magnitude of the increase in BNP is usually greater than the increase in ANP. This makes BNP is a clinically useful diagnostic marker for several pathophysiological conditions, including heart failure, ventricular remodeling and pulmonary hypertension, among others. Recent studies have shown that in addition to BNP-32, proBNP-108 also circulates in human plasma and that levels of both forms are increased in heart failure. Furthermore, proBNP-108 is O-glycosylated and circulates at higher levels in patients with severe heart failure. In this review we discuss recent progress in our understanding of the biochemistry, molecular biology and clinical relevance of the natriuretic peptide system. (C) 2011 Japanese College of Cardiology. Published by Elsevier Ltd. All rights reserved.
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