Journal
JOURNAL OF CARDIOLOGY
Volume 55, Issue 1, Pages 65-68Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jjcc.2009.08.006
Keywords
Colestimide; Hyperlipidemia; Nuclear magnetic resonance; Small dense low-density lipoprotein
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Funding
- Department of the Cardiovascular Medicine, Hokkaido University Hospital
- Ministry of Education, Culture, Sport, Science and Technology of Japan
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Objectives: Recent studies have demonstrated that not only plasma low-density lipoprotein (LDL) levels, but also the number of small dense LDL particles are involved in the development of arteriosclerosis. Anion exchange resins can reduce plasma LDL levels and affect LDL particle size via increasing triglycerides. In the present study, the effects of short-term colestimide administration on LDL particle size were investigated. Methods: Obese patients with primary hyperlipidemia (n = 21) were administered 3000 mg/day of colestimide for 1 month and fasting blood was obtained before and after the treatment. LDL particle size and number were measured by nuclear magnetic resonance (NMR) lipoprofile using magnetic resonance spectroscopy. Results: Levels of plasma LDL cholesterol decreased from 155.5 mg/dl to 128.1 mg/dl (p < 0.001) and levels of apolipoprotein B decreased from 139.2 mg/dl to 120.6 mg/dl (p < 0.001) by colestimide administration. Levels of high-density lipoprotein (HDL) cholesterol and triglyceride were unaltered. LDL particle size did not change, whereas LDL particle numbers decreased from 1920.3 nmol/l to 1568.8 nmol/l (p < 0.01). Conclusions: Short-term administration of colestimide to patients with hyperlipidemia reduced LDL particle numbers. LDL particle size was not changed. (C) 2009 Japanese College of Cardiology. Published by Elsevier Ireland Ltd. All rights reserved.
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