Journal
NEUROCHEMISTRY INTERNATIONAL
Volume 89, Issue -, Pages 75-82Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neuint.2015.08.009
Keywords
Polyphenols; Neuroprotection; Ischemia; CNS injury; Oxidative stress; Inflammation
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Funding
- National Institute of General Medical Sciences of the National Institutes of Health [T32GM081061]
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Resveratrol, a stilbene formed in many plants in response to various stressors, elicits multiple beneficial effects in vertebrates. Particularly, resveratrol was shown to have therapeutic properties in cancer, atherosclerosis and neurodegeneration. Resveratrol-induced benefits are modulated by multiple synergistic pathways that control oxidative stress, inflammation and cell death. Despite the lack of a definitive mechanism, both in vivo and in vitro studies suggest that resveratrol can induce a neuroprotective state when administered acutely or prior to experimental injury to the CNS. In this review, we discuss the neuroprotective potential of resveratrol in stroke, traumatic brain injury and spinal cord injury, with a focus on the molecular pathways responsible for this protection. (C) 2015 Elsevier Ltd. All rights reserved.
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